Comparison 6.

Sensitivity analysis - Fluoxetine vs Heterocyclics

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond - HDRS (−50%)	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 Fluoxetine vs Maprotiline	2	163	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.92 [0.92, 3.98]
1.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.81 [0.27, 2.36]
2 End-point score on HDRS	6		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.6 Fluoxetine vs Maprotiline	3	252	Std. Mean Difference (IV, Random, 95% CI)	0.05 [−0.20, 0.30]
2.7 Fluoxetine vs Mianserin	3	128	Std. Mean Difference (IV, Random, 95% CI)	0.43 [−0.38, 1.23]
3 Failure to complete - Total	4		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
3.1 Fluoxetine vs Maprotiline	2	163	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.05 [0.81, 5.21]
3.2 Fluoxetine vs Mianserin	2	93	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.67 [0.27, 1.70]
4 Failure to complete - Inefficacy	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
4.1 Fluoxetine vs Maprotiline	2	163	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.01 [0.73, 12.41]
4.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.18 [0.40, 11.74]
5 Failure to complete - Side Effects	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
5.1 Fluoxetine vs Maprotiline	2	163	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.69 [0.12, 4.06]
5.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.24, 4.64]