Comparison 7.
Sensitivity analysis - Fluoxetine vs other SSRIs
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Failure to respond - HDRS (−50%) | 13 | Peto Odds Ratio (Peto, Fixed, 95% CI) | Subtotals only | |
| 1.1 Fluoxetine vs Fluvoxamine | 1 | 177 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.95 [0.52, 1.74] |
| 1.2 Fluoxetine vs Paroxetine | 8 | 960 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.25 [0.96, 1.63] |
| 1.3 Fluoxetine vs Sertraline | 6 | 1028 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.34 [1.04, 1.73] |
| 2 End-point score on HDRS | 15 | Std. Mean Difference (IV, Random, 95% CI) | Subtotals only | |
| 2.1 Fluoxetine vs Citalopram | 2 | 610 | Std. Mean Difference (IV, Random, 95% CI) | 0.05 [−0.10, 0.21] |
| 2.2 Fluoxetine vs Paroxetine | 8 | 920 | Std. Mean Difference (IV, Random, 95% CI) | −0.04 [−0.45, 0.37] |
| 2.3 Fluoxetine vs Sertraline | 7 | 1070 | Std. Mean Difference (IV, Random, 95% CI) | 0.08 [−0.04, 0.20] |
| 3 Failure to complete - Total | 17 | Peto Odds Ratio (Peto, Fixed, 95% CI) | Subtotals only | |
| 3.1 Fluoxetine vs Citalopram | 2 | 673 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.87 [0.59, 1.27] |
| 3.2 Fluoxetine vs Fluvoxamine | 2 | 284 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.71 [0.37, 1.36] |
| 3.3 Fluoxetine vs Paroxetine | 7 | 854 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.98 [0.72, 1.34] |
| 3.4 Fluoxetine vs Sertraline | 8 | 1189 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.20 [0.92, 1.56] |
| 4 Failure to complete - Inefficacy | 7 | Peto Odds Ratio (Peto, Fixed, 95% CI) | Subtotals only | |
| 4.1 Fluoxetine vs Citalopram | 2 | 673 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.90 [0.49, 1.65] |
| 4.2 Fluoxetine vs Paroxetine | 2 | 253 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.85 [0.25, 2.84] |
| 4.3 Fluoxetine vs Sertraline | 5 | 896 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.13 [0.62, 2.05] |
| 5 Failure to complete - Side Effects | 16 | Peto Odds Ratio (Peto, Fixed, 95% CI) | Subtotals only | |
| 5.1 Fluoxetine vs Citalopram | 2 | 673 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.57 [0.30, 1.09] |
| 5.2 Fluoxetine vs Fluvoxamine | 1 | 100 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.04 [0.14, 7.63] |
| 5.3 Fluoxetine vs Paroxetine | 7 | 757 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.83 [0.52, 1.34] |
| 5.4 Fluoxetine vs Sertraline | 8 | 1189 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.19 [0.85, 1.66 |