Methods	Six-week double-blind, randomised study.
Participants	Outpatients meeting DSM-IV diagnostic criteria for major depression, with a minimum baseline score of 20 on the HDRS-17. Age range: 19-54 years old. Exclusion criteria: any other psychiatric primary disease, current or past history of bipolar disorder, use of anxiolitic or MAOI or tryptophan, organic mental disorder, epilepsy, suicidal tendencies, any severe general disease, pregnancy, lactation
Interventions	Fluoxetine: 24 participants. Nortriptyline: 24 participants. Fluoxetine dose: 60 mg/day. Nortriptyline dose: 150 mg/day.
Outcomes	Primary outcome: Hamilton Rating Scale for Depression (HDRS-17)
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear