| Methods | Six-week double-blind, randomised study. | |
| Participants | Outpatients (general practice) fulfilling Research Diagnostic Criteria (RDC) criteria for primary uniopolar major depressive disorder, with a score of at least 17 on the HDRS-17. Age range: 18-70. Exclusion criteria: physical illness, use of other antidepressant medication, pregnancy, potential childbearing, lactation |
|
| Interventions | Fluoxetine: 49 participants. Dothiepin: 51 participants. Fluoxetine dose range: 20-60 Dothiepine dose range: 50-100. |
|
| Outcomes | Hamilton Rating Scale for Depression (HDRS-17). | |
| Notes | Funding: by industry | |
| Risk of bias | ||
| Item | Authors’ judgement | Description |
| Allocation concealment? | Unclear | B - Unclear |
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