Methods	Six-week double-blind, randomised study.
Participants	Outpatients fulfilling DSM-III criteria for major depression (unipolar), with a score of at least 17 on the HDRS. Age range: 18-75 years. Exclusion criteria: significant pohysiacl illness, lactation, pregnancy, history of schizophrenia or drug or alcohol abuse, current use of antidepressant
Interventions	Fluoxetine: 30 participants. Dothiepin: 30 participants. Fluoxetine dose range: 20-40 Dothiepine dose range: 100-200. Benzodiazepines were allowed for sedation at the discretion of the doctor
Outcomes	Hamilton Rating Scale for Depression, Montgomery and Asberg Scale for Depression (MADRS), CGI Severity and Improvement, PGI
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear