Methods	Six-week randomised, double-blind study.
Participants	Outpatients fulfilling DSM-III-R criteria for major depressive episode, with a score of at least 18 on the HDRS-21. Age range: 18-65 years old. Exclusion criteria: pregnancy, lactation, hepatic, renal, neurological, gastrointestinal, or severe cardiovascular disease, schizophrenia, organic brain syndrome, unstable diabetes, recent treatment with MAOI, neuroleptics, lithium therapy, ECTin the previous 3 months, alcohol or drug abuse, severe risk of suicide
Interventions	Fluoxetine: 45 participants. Paroxetine: 45 participants. Fluoxetine dose range: 20-60 mg/day. Paroxetine dose range: 20-40 mg/day.
Outcomes	Hamilton Rating Scale for Depression, Montgomery and Asberg Scale for Depression (MADRS), Hamilton Rating Scale for Anxiety
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear