Methods	Twelve-week randomised, double-blind, multicentre study.
Participants	Outpatients (general practice) fulfilling DSM-III-R criteria for major depressive episode, with a score of at least 25 on the MADRS and a MMSE of at least 24. Age range: over 65 years old. Exclusion criteria:
Interventions	Fluoxetine: 122 participants. Tianeptine: 115 participants. Fluoxetine dose: 20 mg/day. Duloxetine dose range: 20-37.5 mg/day.
Outcomes	Primary outcomes: change in the total score on the Montgomery and Asberg Scale for Depression (MADRS). Secondary outcomes: total number of responders at endpoint, total number of remissions at endpoint, measn variation on the Geriatric Depression Scale
Notes	Response: decrease of at least 50% in the MADRS total score. Remission: total score less than 10 on the MADRS. Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear