Methods	Six-week double-blind, randomised, study.
Participants	Outpatients fulfilling DSM-IV criteria for major depressive episode (lasting between 1 week and 1 year), with a score of at least 15 on the HDRS-17. Age range: 18-75 years. Exclusion criteria: pregnancy, lactation, actual suicide risk, history of current diagnosis of bipolar disorder, schizophrenia, psychotic symptoms, organic mental disorder, current diagnosis on DSM-IV of anxiety or eating disorder, epilepsy, alcohol or substance abuse in the perevious 6 months, serious medical diseases
Interventions	Fluoxetine: 66 participants. Mirtazapine: 66 participants. Fluoxetine dose range: 20-40 mg/day. Mirtazapine dose range: 30-45 mg/day.
Outcomes	Hamilton Rating Scale for Depression, CGI.
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear