Methods	Six-week randomised, double-blind, multicentre study.
Participants	In- and outpatients fulfilling DSM-III-R criteria for major depressive disorder (1 month minimum duration of episode), with a score of at least 17 on the HDRS-17. Age range: 21-63. Exclusion criteria: organic mental disorder, substance use disorder, schizophrenia or schizoaffective disorder, paranoid or other psychotic disorder, bipolar disorder, significant physical illness, history of seizures, drug allergy, glaucoma or urinary retention, use of other psychotropic medication (including lithium), pregnancy, lactation
Interventions	Fluoxetine: 30 participants. Amitriptyline : 28 participants. Fluoxetine dose: 20 mg/day. Amitriptyline dose range: 50-200 mg/day. Only temazepam or chloral hydrate were allowed.
Outcomes	Hamilton Rating Scale for Depression (HDRS-17).
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear