Methods	Six-week randomised, double-blind study.
Participants	Inpatients fulfilling Research Diagnostic Criteria for major depressive disorder, with a score of at least 17 on the HDRS. Age range: 18-64 years old. Exclusion criteria: concurrent medical disorder.
Interventions	Fluoxetine: 16 participants. Amitriptyline : 18 participants. Fluoxetine dose range: 40-60 mg/day. Amitriptyline dose range: 100-150 mg/day. Only oxazepam (max 100 mg/day) was allowed.
Outcomes	Hamilton Rating Scale for Depression, Montgomery and Asberg Scale for Depression (MADRS), CGI Severity and Improvement, PGI,
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear