Methods	Five-week randomised, double-blind study.
Participants	Outpatients with depressive syndrome with a score of at least 17 on the HDRS and 8 on the Raskin. Age range: 19-74 years old. Exclusion criteria: severe organic illness, evidence of psychosis, psychopathic disorder, addictive illness, suicide tendencies, a period of less than 4 weeks since the last treatment with amitriptyline or neuroleptics
Interventions	Fluoxetine: 63 participants. Amitriptyline : 65 participants. Fluoxetine dose range: 20-60 mg/day. Amitriptyline dose range: 50-150 mg/day. Chloral derivative was allowed (eventually changed in flurazepam or nitrazepam only if its effects was inadequate)
Outcomes	Hamilton Rating Scale for Depression (HDRS), CGI, Raskin Depression Scale, Covi Anxiety Scale, PGI
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear