Methods	Six-week randomised, double-blind, two-centre study.
Participants	In- and outpatients fulfilling Research Diagnostic Criteria for major depressive disorder, with a score of at least 17 on the HDRS. Mean age: 46.1 (fluoxetine) and 45.4 (imipramine) years. Exclusion criteria: significant physical illness, history of drug abuse, schizophrenia, duration of illness more than 1 year
Interventions	Fluoxetine: 30 participants. Imipramine: 30 participants. Fluoxetine dose range: 40-60 mg/day. Imipramine dose range: 75-150 mg/day. Only temazepam was allowed for night sedation.
Outcomes	Hamilton Rating Scale for Depression, Montgomery and Asberg Scale for Depression, LPD
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear