Methods	Six-week randomised, double-blind study.
Participants	Outpatients fulfilling DSM-III-R criteria for non-psychotic depressive episode (no longer than 5 months), with a score of at least 21 on the HDRS and no more than 2 previous antidepressive drugs given for the current episode and no medication for 3-5 days before first assessment. Age range: 25-50 years old. Exclusion criteria: psychotic state, significant past head injury, severe neurological disease of physical illness, history of drug addiction or alcoholism, ECT in the last year, suicide risk, or suicide attempt in the last year
Interventions	Fluoxetine: 8 participants. Desipramine: 9 participants. Fluoxetine dose: 20 mg/day. Desipramine dose range: 125-200 mg/day.
Outcomes	Hamilton Rating Scale for Depression (HDRS-17), CGI.
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear