Methods	Five-week randomised, double-blind study.
Participants	Patients fulfilling DSM-III criteria for major depressive episode, with a score of at least 18 on the first 17 items of the HDRS. Age range: 18-65 years old. Exclusion criteria: pregnancy, serious vascular disease, hyperthyroidism, glaucoma, urinary retention, hepatic, respiratory or renal marked failure, hematological disease, organic brain disease, seizures, alcohol and/or drug abuse
Interventions	Fluoxetine: 15 participants. Imipramine: 15 participants. Fluoxetine dose: 20 mg/day. Imipramine dose range: 100-150 mg/day.
Outcomes	Hamilton Rating Scale for Depression, CGI.
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear