Methods	Six-week randomised, double-blind study.
Participants	Outpatients fulfilling DSM-III-R criteria for major depressive illness, with a score of at least 20 on the HDRS, a score of at least 8 on the Raskin and greater than the Covi Anxiety Scale score. Mean age: 51 years old in both groups. Exclusion criteria: not stated.
Interventions	Fluoxetine: 20 participants. Amitriptyline : 21 participants. Fluoxetine dose range: 40-80 mg/day. Amitriptyline dose range: 150-300 mg/day.
Outcomes	Hamilton Rating Scale for Depression (HDRS-17), Raskin Depression Scale, Covi Anxiety Scale, CGI-Improvement and Severity, PGI
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear