Methods	Eight-week double-blind, randomised study.
Participants	Outpatients fulfilling DSM-III and Bech-Rafaelsen Melancholia Scale criteria for major depressive disorder, with a score of at least 18 on the HDRS-21. Age range: 18-70 years old. Exclusion criteria: suicide risk, history of schizophrenia or organic brain disfunction, history of severe allergies or serious physical illness, recent period of alcohol or alcohol abuse, pregnancy
Interventions	Fluoxetine: 29 participants. Imipramine: 30 participants. Fluoxetine dose: 20 mg/day. Imipramine dose range: 75-150 mg/day.
Outcomes	Hamilton Rating Scale for Depression (HDRS-21), Bech-Rafaelsen Melancholia Scale, CGI, PGI
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear