Methods	Five-week randomised, double-blind study.
Participants	Outpatients fulfilling ICD 9 criteria for major unipolar or bipolar depression, with a score of at least 17 on the HDRS, a score of at least 8 on the Raskin, greater than Covi. Age range: 25-63 years old. Exclusion criteria: history of psychosis, suicide risk, severe mental diseses, controindication to amitriptyline, severe organic disease, known drug allergy, use of amitrièptyline within 4 weeks of baseline, use of neuroleptics within 2 weeks of study entry
Interventions	Fluoxetine: 51 participants. Amitriptyline : 51 participants. Fluoxetine dose: 20 mg/day. Amitriptyline dose: 100 mg/day. Chloral hydrate or benzodiazepines for insomnia were allowed
Outcomes	Hamilton Rating Scale for Depression (HDRS-17), CGI, Raskin Depression Scale, Covi Anxiety Scale
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear