Methods	Six-week randomised, double-blind study.
Participants	In- and outpatients fulfilling DSM-III-R criteria for major depressive disorder (lasting 1 month or more), with a score of at least 20 on the HDRS-21. Age range: 18-65 years old. Exclusion criteria: any abnormalities on laboratory examination, presence of psychosis, bipolar disorder, conscurrent use of any psychoactive medication, pregnancy, lactation
Interventions	Fluoxetine: 26 participants. Desipramine: 20 participants. Fluoxetine dose range: 20-60 mg/day. Desipramine dose range: 150-300 mg/day.
Outcomes	Hamilton Rating Scale for Depression, CGI, PGI.
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear