Methods	RCT, DB, parallel groups Cream applied three times daily for 5 days, with elastic support for the first 3 days Assessed at baseline 4, 8 days
Participants	Sprained ankle (<24 hours) N = 100 M 58, F 42 Mean age 28 years Baseline pain: all participants had “walking pain”
Interventions	Benzydamine 3% cream, 3 × daily, n = 50 Placebo gel, n = 50
Outcomes	Pain on movement: responder = “free of walking pain” Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1 Total = 3/5 Oxford Validity Score: 9/16
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described