Comparison 1. All topical NSAIDs vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical success	31	3462	Risk Ratio (M-H, Fixed, 95% CI)	1.53 [1.43, 1.63]
2 Clinical success (study size)	31		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
2.1 Study size <40 participants per treatment arm	13	681	Risk Ratio (M-H, Fixed, 95% CI)	1.71 [1.51, 1.95]
2.2 Study size ≥40 participants per treatment arm	18	2774	Risk Ratio (M-H, Fixed, 95% CI)	1.47 [1.36, 1.58]
3 Clinical success (preferred outcome)	31		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
3.1 Preferred outcome	23	2857	Risk Ratio (M-H, Fixed, 95% CI)	1.53 [1.42, 1.64]
3.2 Other outcome	8	598	Risk Ratio (M-H, Fixed, 95% CI)	1.49 [1.29, 1.71]
4 Clinical success (treatment duration)	31		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
4.1 Treatment duration 6-8 days	26	2786	Risk Ratio (M-H, Fixed, 95% CI)	1.60 [1.49, 1.73]
4.2 Treatment duration 10-14 dayks	5	662	Risk Ratio (M-H, Fixed, 95% CI)	1.24 [1.10, 1.40]
5 Local adverse events	30	3786	Risk Ratio (M-H, Fixed, 95% CI)	1.11 [0.88, 1.41]