Table 1. Summary of outcomes: successful treatment.
| Study ID | Treatment | Clinical response | Other response |
|---|---|---|---|
| Airaksinen 1993 |
|
PGE “improved” at 7 days
|
No additional data |
| Akermark 1990 |
|
No pain on palpation at 7 days
|
Patient assessment of improvement at 7 days (Scale 0-100)
|
| Aoki 1984 |
|
PGE (5 point) “better or much better” at 7 days
|
Pain on movement “reduced” or “disappeared” at 7 days:
|
| Auclair 1989 |
|
PGE (5 point) “good or very good” at 7 days
|
Pain on palpation “improved” at 7 days
|
| Billigmann 1996 |
|
Complete remission
|
Improvement in pain with movement of 20% at 7 days
|
| Campbell 1994 |
|
Improvement in walking ability (4 point) at 7 days
|
No additional data |
| Chatterjee 1977 |
|
Pain on movement “absent/slight” at 6 days
|
Tenderness with pressure “absent/slight” at 6 days
|
| Curioni 1985 |
|
Resolution of symptoms by 7 days
|
PGE “good” or “excellent” at 10 days
|
| Diebshlag 1990 |
|
Improvement in pain at 7 days
|
No additional data |
| Dreiser 1988 |
|
PGE “improvement” or “complete relief” at 7 days
|
(1) significantly better than (2) for mean improvement in spontaneous pain, movement pain, rest pain, tenderness to pressure (VAS) |
| Dreiser 1989 |
|
PGE (3 point) “better” at 7 days
|
(1) significantly better than (2) for mean improvement in pain (rest and movement) (VAS) |
| Dreiser 1990 |
|
PGE (4 point) “cured” or “improved” at 7 days
|
(1) significantly better than (2) for mean improvement in pain (VAS) |
| Dreiser 1994 |
|
PGE (4 point) “good” or “very good” at 7 days
|
(1) significantly better than (2) for mean improvement in spontaneous pain, but not pain on movement or palpation (VAS) |
| Fioravanti 1999 |
|
PGE (4 point) “good” or “excellent” at 10 days
|
(1) significantly better than (2) for mean improvement in spontaneous pain at 7 days, but not for pain on movement at 10 days (VAS) |
| Fujimaki 1985 |
|
PGE (5 point) “better” or “much better” at end of treatment at 14 days
|
No additional data |
| Gallacchi 1990 |
|
PGE (5 point) “good” or “excellent” at 14 days
|
No significant difference between groups for pain on applied pressure at 7 and 14 days |
| Governali 1995 |
|
PGE (5 point) “good” or “excellent” at 7 days
|
No additional data |
| Gualdi 1987 |
|
No dichotomous data | No significant difference between groups for pain on movement at 7 days |
| Haig 1986 |
|
Pain on movement “improved” by 6 days
|
No additional data |
| Hofman 2000 |
|
PGE (3 point) at 8 days: “good”
|
No significant difference between treatments for any pain outcomes |
| Hosie 1993 |
|
Pain on movement “none” or “mild” at 7 days
|
Spontaneous pain “none” or “mild” at 7 days
|
| Jenoure 1997 |
|
Baseline pain in two groups not balanced, and data in table and figure do not agree, so efficacy outcomes not used | No additional data |
| Joussellin 2003 |
|
PGE (4 point) “excellent” at 7 days
|
(1) significantly better than (2) for mean pain on movement at 6 days |
| Julien 1989 |
|
PGE (4 point) “recovered” at 7 days
|
PGE (4 point) “recovered” or “improved” at 7 days
|
| Kockelbergh 1985 |
|
PGE (3 point) “good” at 7 days
|
(1) and (2) slightly better than (3) for mean spontaneous pain at 7 days |
| Linde 1985 |
|
No pain on movement (walking) at 8 days
|
No additional data |
| Machen 2002 |
|
PGE: (5 point) “marked improvement” or “complete clearance” at 7 days
|
Clinically meaningful (≥30 mm) pain relief at day 7
|
| Mahler 2003 |
|
PGE (4 point) “good” or “excellent” at 10 days
|
Mean reduction in pain on movement at 3 and 10 days significantly greater with (1)than (2) |
| Mazieres 2005a |
|
PGE (4 point) “good” or “excellent” at 14 days
|
All mean efficacy measures improved more for (1) than (2), most were statistically significant |
| Mazieres 2005b |
|
PGE (4 point) “good” or “excellent” at 14 days
|
All mean efficacy measures improved more for (1) than (2), most were statistically significant |
| McLatchie 1989 |
|
No dichotomous data | Patient daily self-assessment for mean pain on rest, movement, at night, interference with normal and leisure activities show better efficacy for (1) than (2) from day 2 (VAS) |
| Morris 1991 |
|
PGE (5 point) “good” or “very good” at 7 days
|
(1) better than (2) for mean improvement in symptoms and sporting function at 7 days |
| Noret 1987 |
|
PGE (4 point) “good” or “excellent” at 8 days
|
Decrease in mean spontaneous pain significantly greater in (1) than (2) by 3 days |
| Parrini 1992 |
|
No dichotomous data | Mean pain on movement and pressure significantly decreased by 7 days in (1) compared with (2) |
| Picchio 1981 |
|
No pain on movement at 8 days
|
Spontaneous pain “none” at 8 days
|
| Predel 2004 |
|
PGE (4 point) “good” “excellent” at 7 days
|
(1) better than (2) for reduction in tenderness, pain, and speed of pain reduction |
| Ramesh 1983 |
|
Pain on movement (4 point) “none” or “slight” at 7 days
|
Physician global assessment at 10 days: “good”
|
| Rowbotham 2003 |
|
Pain intensity ≤2/10 for 2 days or 4 consecutive evaluations, by 7 days
|
Mean pain on rest significantly better with (1) than (2) after 7 days |
| Russell 1991 |
|
PGE (4 point) “good” or “excellent” at 8 days
|
Statistically greater red in mean pain on movement at 8 days with (1) than (2) |
| Sanguinetti 1989 |
|
PGE “good” or “very good” at 7 days
|
(1) better than (2) by 2 days |
| Sinneger 1981 |
|
Complete pain reliefwithin 10 days
|
Improvement in active pain on movement at 5 days
|
| Spacca 2005 |
|
No dichotomous data | Mean pain scores improved more rapidly in (1) than (2) - statistically significant at 3 and 6 days |
| Sugioka 1984 |
|
PGE (5 point) “better” or “much better” at 14 days
|
Pain on movement “reduced” or “disappeared” at 7 days
|
| Thorling 1990 |
|
PGE (5 point) “good” or “very good” at 7 days
|
Participants using naproxen improved more rapidly and had significantly lower severity scores by day 3 |
| Tonutti 1994 |
|
PGE (4 point) “good” or “excellent” at 7 days
|
Significant reductions in pain on movement by 7 days in both groups |
| Vecchiet 1989 |
|
PGE (4 point) “good” or “excellent” at 10 days
|
(1) significantly better than (2) for mean improvement in spontaneous pain, movement pain, functional restriction |
| Whitefield 2002 |
|
Patient satisfied at 7 days
|
“Completely better” at 14 days
|
PGE - patient global evaluation; VAS - visual analogue scale