Methods | Allocation: ‘randomly assigned’. Blinding: not reported. Setting: psychiatric hospital, Suzhou, China. Inclusion criteria: male, just discharged after first episode for schizophrenia, no other medical conditions. Follow-up: 18 months. Evaluation: by ‘attending physicians’ blind to allocation. |
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Participants | Diagnosis: schizophrenia (Chinese Medical Association Criteria). N=83. Age: mean 23.8. Sex: all male. History: mean DUP 34.6 months. |
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Interventions | 1. Family psychoeducation in individual and group sessions plus standard out-patient care. N=42 2. Out-patient care. N=41. |
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Outcomes | Readmitted. Lost to follow-up. Compliant with medication. Unable to use - Chlorpromazine equivalent dosage of medication: (not a clinical or social outcome). Mental state: Chinese BPRS (excluded readmitted patients). Overall functioning: Chinese GAS (excluded readmitted patients) |
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Notes | First Episode Trial - phase-specific treatment plus standard care versus standard care | |
Risk of bias | ||
Bias | Authors’ judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Randomised, no further details. |
Allocation concealment? | Unclear risk | No details. |
Blinding? All outcomes |
High risk | Not reported. |
Incomplete outcome data addressed? All outcomes |
Low risk | Study attrition reported. |
Free of selective reporting? | Unclear risk | No details. |
Free of other bias? | Unclear risk | No details. |
CAARMS - Comprehensive Assessment of At-Risk Mental States
COPS - Criteria of Prodromal Syndromes
DSM - Diagnostic and Statistical Manual
ICD-10 - International Classification of Diseases
SIPS - Structured Interview for Prodromal Syndromes
Rating Scales:
Mental state
BDI - Beck Depression Inventory
BPRS - Brief Psychiatric Rating Scale
CDRS - Calgary Depression Rating Scale
HRSA - Hamilton Rating Scale for Anxiety
HRSD - Hamilton Rating Scale for Depression
MADRS - Mongomery and Asberg Depression Rating Scale
PANSS - Positive and Negative Symptom Scale
POPS - Presence of Psychosis Scale
SANS - Schedule for the Assessment of Negative Symptoms
SOPS - Scale of Prodromal Symptoms
YMRS - Young Mania Rating Scale
YMS - Young Mania Scale
Global state
CGI - Clinical Global Impression
GAF - Global Assessment of Functioning
GAS - Global Adjustment Scale
Adverse effects
AIMS - Abnormal and Involuntary Movement Scales
BAS - Barnes Akathisia Scale
SAS - Simpson & Angus
User satisfaction
CSQ-8 - Client Satisfaction Questionnaire-8
Others
APQ - Alcohol Problems Questionnaire
DUP - Duration of untreated psychosis
EM - Explanatory Model scale
EIPS - early initial prodromal state
GSI - General Symptom Index of the SCL-90-R
IS/O - Integration/Sealing Over
IPS - Individual Placement and Support
ITT - Intention to Treat
LOCF - Last Observation Carried Forward
MCQ - Meta-Cognitions Questionnaire
OLIFE - Oxford-Liverpool Inventory of Feelings and Experiences
PACE - Personal Assessment and Crisis Evaluation
QLS - Quality of Life Scale
RCI - Reliable Change Index
SAC - Sociotropy - Autonomy Scale
TAU - Treatment as Usual
UHR - Ultra high risk (of developing psychosis)