Methods | Allocation: randomised, no further details. Blinding: double blind. Setting: Vienna, Austria. Inclusion criteria: not stated. Exclusion criteria: not stated. Follow up: 12 weeks. |
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Participants | Diagnosis: Adolescents at risk of 1st episode psychosis (Yung criteria). N=81*. Age: range 3-24 years; mean age 16.4. Sex: no details. History: no details. |
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Interventions | 1. Omega-3 fatty acids: dose eicosapentaenoic acid 0.84 g/day; docosahexaenoic acid 0.7 g/day. N=38. 2. Placebo. N=38. |
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Outcomes | Transition to psychosis**. Unable to use - Leaving the study early Mental state: BPRS, PANSS (no usable data) Global state: GAF (no usable data). Adverse effects: UKU. |
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Notes | *5 participants not accounted for. **Operationally defined, based on Yung et al’s criteria, using cut-off points on PANSS subscales, (4 or more on hallucinations, 4 or more on delusions, and 5 or more on conceptual disorganization), and the frequency of symptoms (at least several times a week) and their duration (more than one week) |
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Risk of bias | ||
Bias | Authors’ judgement | Support for judgement |
Adequate sequence generation? | Unclear risk | Randomised, no further details. |
Allocation concealment? | Unclear risk | No described. |
Blinding? All outcomes |
Unclear risk | Double blind, untested. |
Incomplete outcome data addressed? All outcomes |
High risk | Study attrition not described. |
Free of selective reporting? | Unclear risk | No details. |
Free of other bias? | Unclear risk | No details. |