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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jun 15;(6):CD004718. doi: 10.1002/14651858.CD004718.pub3
Methods Allocation: randomised, no further details.
Blinding: double blind.
Setting: Vienna, Austria.
Inclusion criteria: not stated.
Exclusion criteria: not stated.
Follow up: 12 weeks.
Participants Diagnosis: Adolescents at risk of 1st episode psychosis (Yung criteria).
N=81*.
Age: range 3-24 years; mean age 16.4.
Sex: no details.
History: no details.
Interventions 1. Omega-3 fatty acids: dose eicosapentaenoic acid 0.84 g/day; docosahexaenoic acid 0.7 g/day. N=38.

2. Placebo. N=38.
Outcomes Transition to psychosis**.

Unable to use -
Leaving the study early
Mental state: BPRS, PANSS (no usable data)
Global state: GAF (no usable data).
Adverse effects: UKU.
Notes *5 participants not accounted for.
**Operationally defined, based on Yung et al’s criteria, using cut-off points on PANSS subscales, (4 or more on hallucinations, 4 or more on delusions, and 5 or more on conceptual disorganization), and the frequency of symptoms (at least several times a week) and their duration (more than one week)
Risk of bias
Bias Authors’ judgement Support for judgement
Adequate sequence generation? Unclear risk Randomised, no further details.
Allocation concealment? Unclear risk No described.
Blinding?
All outcomes
Unclear risk Double blind, untested.
Incomplete outcome data addressed?
All outcomes
High risk Study attrition not described.
Free of selective reporting? Unclear risk No details.
Free of other bias? Unclear risk No details.