Comparison 7. Adverse events and other outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality ‐ All Studies	22	1788	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.49, 1.88]
2 Mortality ‐ Active vs Control	16		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Active vs Control	16	1132	Risk Ratio (M‐H, Random, 95% CI)	1.41 [0.66, 3.05]
3 Mortality ‐ Active vs Active	6	656	Risk Ratio (M‐H, Random, 95% CI)	0.27 [0.07, 1.08]
4 Re‐operation for bleeding ‐ All Studies	19	1683	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.53, 1.53]
5 Re‐operation for bleeding ‐ Active vs Control	10		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Active vs Control	10	688	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.45, 2.24]
6 Re‐operation for bleeding ‐ Active vs Active	9	995	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.41, 1.68]
7 Any infection ‐ All Studies	23	2892	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.46, 0.99]
8 Any infection ‐ Active vs Control	16		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
8.1 Active vs Control	16	1860	Risk Ratio (M‐H, Random, 95% CI)	0.63 [0.41, 0.96]
9 Any Infection ‐ Active vs Active	7	1032	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.37, 2.07]
10 Wound complication ‐ All Studies	16	1962	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.57, 1.55]
11 Wound complication ‐ Active vs Control	12		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
11.1 Active vs Control	12	1464	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.49, 1.57]
12 Wound complication ‐ Active vs Active	4	498	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.43, 2.99]
13 Any thrombosis ‐ All Studies	11	925	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.48, 2.66]
14 Any thrombosis ‐ Active vs Control	10		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
14.1 Active vs Control	10	807	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.48, 2.66]
15 Stroke ‐ All Studies	7	696	Risk Ratio (M‐H, Random, 95% CI)	0.64 [0.21, 1.98]
16 Stroke ‐ Active vs Control	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
16.1 Active vs Control	5	439	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.20, 3.21]
17 Stroke ‐ Active vs Active	2	257	Risk Ratio (M‐H, Random, 95% CI)	0.43 [0.06, 2.90]
18 Non‐fatal myocardial infarction ‐ All Studies	11	951	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.43, 1.46]
19 Non‐fatal myocardial infarction ‐ Active vs Control	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
19.1 Active vs Control	6	509	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.32, 1.31]
20 Non‐fatal myocardial infarction ‐ Active vs Active	5	442	Risk Ratio (M‐H, Random, 95% CI)	1.46 [0.43, 4.88]
21 Deep vein thrombosis (DVT)	7		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
21.1 Active vs Control	7	645	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.31, 2.23]
22 Hospital length of stay (LOS) ‐ Active vs Control	10		Mean Difference (IV, Random, 95% CI)	Subtotals only
22.1 Active vs Control	10	772	Mean Difference (IV, Random, 95% CI)	‐1.38 [‐2.79, 0.03]
23 Hospital length of stay (LOS) ‐ Active vs Active	1	196	Mean Difference (IV, Random, 95% CI)	2.8 [‐2.11, 7.71]
23.1 Active vs Active	1	196	Mean Difference (IV, Random, 95% CI)	2.8 [‐2.11, 7.71]