Methods	RCT
Participants	Women with BMI 24-29 (Germany) CVD risk: low Control: randomised 35, analysed 32 Intervention: randomised 35, analysed 35 Mean years in trial: control 0.7, intervention 0.8 % male: 0 Age: mean control 46, intervention 48 (all 40-60)
Interventions	Reduced fat vs usual diet Control aims: advice to buy foods from trial shop, usual fat foods supplied Intervention aims: advice to buy foods from trial shop, low fat foods supplied Control methods: trial shop provided ad libitum usual fat foods Intervention methods: trial shop provided ad libitum low fat foods Total fat intake (at 9 months): low fat 35.1 (sd unclear), cont 35.5 (sd unclear)%E Saturated fat intake: unclear Style: food provided Setting: community
Outcomes	Stated trial outcomes: weight Data available on total mortality? yes (no events) Cardiovascular mortality? yes (no events) Events available for combined cardiovascular events: cardiovascular deaths, non-fatal MI, stroke (no events) Secondary outcomes: total and non-fatal MI, stroke, cancer deaths (no events for any outcomes) Tertiary outcomes: weight, total, LDL and HDL cholesterol, TG
Notes
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	“participants assigned to a random number, later numbers sorted & assigned”
Allocation concealment (selection bias)	Unclear risk	Randomisation method not clearly described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Blinding unclear for participants and researchers
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Unclear, deaths, cancer and CV events are drop-outs, trialists asked for data - unclear if any data missing
Selective reporting (reporting bias)	Low risk	Not relevant for primary and secondary outcomes as all trialists asked for data
Other bias	Low risk
Free of systematic difference in care?	Low risk	Trial shop for both groups. See Control and Intervention Methods in Interventions section of the Table of Characteristics of Included Studies
Free of dietary differences other than fat?	Low risk	See Control and Intervention Aims in Interventions section of the Table of Characteristics of Included Studies