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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jul 6;(7):CD002137. doi: 10.1002/14651858.CD002137.pub2

Comparison 3. fat modification or reduction vs usual diet - tertiary outcomes.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Weight, kg 18 Mean Difference (IV, Random, 95% CI) Subtotals only
 1.1 Modified fat intake 2 99 Mean Difference (IV, Random, 95% CI) −1.10 [−3.14, 0.93]
 1.2 Reduced fat intake 16 11058 Mean Difference (IV, Random, 95% CI) −0.83 [−1.37, −0.30]
 1.3 Reduced and modified fat intake 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
2 BMI, kg/m2 14 Mean Difference (IV, Random, 95% CI) Subtotals only
 2.1 Modified fat intake 2 116 Mean Difference (IV, Random, 95% CI) −0.34 [−0.99, 0.31]
 2.2 Reduced fat intake 10 5972 Mean Difference (IV, Random, 95% CI) −0.47 [−0.72, −0.23]
 2.3 Reduced and modified fat intake 2 111 Mean Difference (IV, Random, 95% CI) −0.20 [−1.30, 0.91]
3 LDL cholesterol, mmol/L 20 Mean Difference (IV, Random, 95% CI) Subtotals only
 3.1 Modified fat intake 2 116 Mean Difference (IV, Random, 95% CI) −0.20 [−0.47, 0.07]
 3.2 Reduced fat intake 14 6971 Mean Difference (IV, Random, 95% CI) −0.10 [−0.14, −0.05]
 3.3 Reduced and modified fat intake 4 627 Mean Difference (IV, Random, 95% CI) −0.21 [−0.35, −0.08]
4 HDL cholesterol, mmol/Lkg 22 Mean Difference (IV, Random, 95% CI) Subtotals only
 4.1 Modified fat intake 3 152 Mean Difference (IV, Random, 95% CI) −0.04 [−0.18, 0.09]
 4.2 Reduced fat intake 15 7082 Mean Difference (IV, Random, 95% CI) −0.01 [−0.02, 0.01]
 4.3 Reduced and modified fat intake 4 2073 Mean Difference (IV, Random, 95% CI) −0.01 [−0.04, 0.01]
5 Total cholesterol, mmol/L 28 Mean Difference (IV, Random, 95% CI) Subtotals only
 5.1 Modified fat intake 8 2280 Mean Difference (IV, Random, 95% CI) −0.44 [−0.60, −0.28]
 5.2 Reduced fat intake 15 7602 Mean Difference (IV, Random, 95% CI) −0.10 [−0.14, −0.05]
 5.3 Reduced and modified fat intake 5 2131 Mean Difference (IV, Random, 95% CI) −0.26 [−0.47, −0.04]
6 Triglycerides, mmol/L 21 Mean Difference (IV, Random, 95% CI) Subtotals only
 6.1 Modified fat intake 5 706 Mean Difference (IV, Random, 95% CI) −0.11 [−0.22, −0.00]
 6.2 Reduced fat intake 13 6875 Mean Difference (IV, Random, 95% CI) −5.09 [−3.25, 3.24]
 6.3 Reduced and modified fat intake 3 218 Mean Difference (IV, Random, 95% CI) −0.27 [−0.53, −0.00]
7 Systolic Blood Pressure, mmHg 7 4059 Mean Difference (IV, Random, 95% CI) −0.67 [−1.61, 0.28]
 7.1 Modified fat intake 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
 7.2 Reduced fat intake 6 3981 Mean Difference (IV, Random, 95% CI) −0.56 [−1.52, 0.40]
 7.3 Reduced and modified fat intake 1 78 Mean Difference (IV, Random, 95% CI) −5.08 [−11.22, 1.06]
8 Diastolic Blood Pressure, mmHg 7 3621 Mean Difference (IV, Random, 95% CI) −0.40 [1.00, 0.20]
 8.1 Modified fat intake 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
 8.2 Reduced fat intake 6 3543 Mean Difference (IV, Random, 95% CI) −0.35 [−0.96, 0.26]
 8.3 Reduced and modified fat intake 1 78 Mean Difference (IV, Random, 95% CI) −2.31 [−6.20, 1.58]