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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Proteomics Clin Appl. 2014 Feb 16;8(0):168–177. doi: 10.1002/prca.201300058

Figure 2.

Figure 2

Spectral counting of TGFBIp tryptic (A) and semi-tryptic peptides (B) obtained from the MS analyses of corneal amyloid deposits from sibling 1 (gray), sibling 2 (white), and corneal stroma control tissue (black). Spectral counts from tryptic peptides indicate that the polypeptide region encompassed by the tryptic peptide Y571-R588 as well as peptides from the C-terminus of the FAS1-3 domain (Y488-R496) and the inter-domain region between the FAS1-3 and FAS1-4 domains (V497-K510) were accumulated in the amyloid deposits of both siblings, when compared to control tissue. Furthermore, according to the spectral counting of semi-tryptic peptides the same regions including peptide F515-R533 from the N-terminal part of the FAS1-4 domain appeared to be processed to a significantly higher extent than seen for the control tissue.