Figure 1.

1. ‘IOP event’ is defined as a 4-day post-injection visit intraocular pressure(IOP) ≥30mmHg which also increased ≥10mmHg from the pre-injection IOP.

2. Pre-injection IOP (measured the day of the offending injection) = 16 and 21. Post-injection IOP (measured the day of offending injection) = 21 (missing for one). One eye was phakic at the time of offending injection. Neither eye had a history of ocular hypertension at baseline.

3. Pre-injection IOP (measured the day of the offending injection) = 19. Post-injection IOP (measured the day of offending injection) = missing. Eye was phakic at the time of offending injection. Eye did not have a history of ocular hypertension at baseline.

4. Pre-injection IOP (measured within 1 week before the offending injection) = 15, 16, 16, and 19. Post-injection IOP (measured the day of offending injection) = 23 and 40 (missing for 2). Two eyes were phakic at the time of offending injection.

5. Pre-injection IOP (measured within 1 week before the offending injection, with the exception of one measured 22 days prior to injection) = 14, 16, 19, 19, 20, 20, 21, and 21. Post-injection IOP (measured the day of offending injection)=17, 28, 28, 32, and 32 (missing for 3). Five eyes were phakic at the time of offending injection. One eye had a cataract extraction on the day of injection.

6. One eye had 2 IOP events: one event following the initial injection and one event following a subsequent injection 4 months later.

7. ‘Not resolved‘ is defined as IOP >30 or on IOP lowering medication at last available study visit; ‘resolved’ defined as IOP <30 and not on IOP lowering medication at last available study visit