TABLE 1.
Vertebral phenotypes of compound Wnt3avt Cdx1 mutantsa
| Phenotypea | No. (%) with genotype:
|
||||||
|---|---|---|---|---|---|---|---|
| Wild type (n = 14) | Wnt3avt/vt or Wnt3avt/+ (n = 20) | Cdx1+/− (n = 18) | Cdx1−/− (n = 29)b | Wnt3avt/vt Cdx1+/− (n = 20) | Wnt3avt/vt Cdx1+/− (n = 21) | Wnt3avt/vt Cdx1−/− (n = 20) | |
| Basioccipital fusion to AAA | 2 (11) | 29 (100) | 2 (10) | 9 (43) | 20 (100) | ||
| Vertebra 1 | |||||||
| Malformed NA | 3 (17) | 6 (30) | 5 (24) | ||||
| Fusion to occipitals | 29 (100) | 18 (90) | |||||
| Vertebra 2 | |||||||
| C1 identity (AAA and/or thick NA) | 10 (56) | 29 (100) | 12 (60) | 20 (96) | 20 (100) | ||
| Malformed NA | 2 (11) | 8 (40) | 18 (86) | ||||
| Vertebra 3 | |||||||
| C2 identity | 29 (100) | 4 (19) | 20 (100) | ||||
| Malformed NA | 1 (6) | 4 (14) | 5 (24) | 1 (5) | |||
| NA fusions | |||||||
| V1-V2 | 1 (6) | 6 (30) | 3 (14) | ||||
| V2-V3 | 1 (6) | 4 (19) | |||||
| TA on vertebra 7 instead of vertebra 6 | 28 (97) | 1 (5) | 4 (19) | 20 (100) | |||
| Vertebra 8 | |||||||
| C7 identity | 11 (38) | 2 (10) | |||||
| Incomplete ribs | 18 (62) | 11 (55) | |||||
a
AAA, anterior arch of the atlas; NA, neural arch; TA, anterior tuberculi.
b
From Allan et al. (1).