TABLE 5.

Comparison of Significant Variables From the Multivariate Analyses Among the Four Mood Trajectory Classes^a

	Class 1 Versus Class 2			Class 1 Versus Class 3			Class 1 Versus Class 4			Class 2 Versus Class 3			Class 2 Versus Class 4			Class 3 Versus Class 4
Variable	Odds Ratio	CI	p	Odds Ratio	CI	p	Odds Ratio	CI	p	Odds Ratio	CI	p	Odds Ratio	CI	p	Odds Ratio	CI	p
Child variables
Age at onset of mood symptoms	1.15	1.06, 1.25	<0.001	1.18	1.08, 1.29	<0.001	1.28	1.16, 1.41	<0.001	—	—	—	1.11	1.02, 1.21	0.02	—	—	—
Severity of manic or hypomanic symptoms at baseline	—	—	—	0.96	0.93, 0.99	0.005	—	—	—	0.96	0.93, 0.99	0.008	—	—	—	—	—	—
Severity of depression at baseline	0.95	0.92, 0.98	0.004	0.95	0.92, 0.99	0.01	0.95	0.91, 0.9	0.009	—	—	—	—	—	—	—	—	—
History of .>1 subsyndromal episode	0.36	0.18, 0.72	0.004	0.32	0.15, 0.69	0.004	—	—	—	—	—	—	—	—	—	—	—	—
History of suicide attempt	0.39	0.18, 0.84	0.02	—	—	—	0.34	0.14, 0.81	0.02	—	—	—	—	—	—	—	—	—
Sexual abuse	0.06	0.007, 0.48	0.008	—	—	—	0.06	0.007, 0.55	0.01	—	—	—	—	—	—	—	—	—
Family variables^b
Lifetime family history of bipolar disorder	0.36	0.19, 0.70	0.003	—	—	—	0.31	0.15, 0.67	0.003	—	—	—	—	—	—	0.49	0.24, 0.99	0.05
Lifetime family history of substance abuse	—	—	—	—	—	—	0.22	0.09, 0.54	<0.001	—	—	—	0.34	0.15, 0.75	0.008	—	—	—

Class 1: predominantly euthymic; class 2: moderately euthymic; class 3: ill with improving course; class 4: predominantly ill.

There were significant interactions between socioeconomic status and child’s age at onset of mood symptoms and child’s severity of depression. The effects of age at onset decreased in youths with lower socioeconomic status, and the effects of depression severity decreased in those with higher socioeconomic status.