Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mutation of JAK2 at tyrosines 221 and 570 affects the ability of JAK2 to phosphorylate Stat5b. 293T cells expressing the cDNA for Stat5b and either JAK2, JAK2 Y221F, JAK2 Y570F, JAK2 Y1007F, or vector were lysed, resolved on SDS-PAGE gels, and blotted (IB) with α-Stat5b, α-phosphoStat5b, α-pY(1007,1008) JAK2, antiphosphotyrosine (α-PY), or α-JAK2, as indicated. The migrations of Stat5b and JAK2 are indicated.
