Comparison 13. Oxytocin alone vs vaginal PGE2: all women, ruptured membranes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Vaginal delivery not achieved in 24 hours	1	20	Risk Ratio (M‐H, Fixed, 95% CI)	2.25 [1.02, 4.94]
2 Uterine hyperstimulation with FHR changes	6	738	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Caesarean section	14	3635	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.85, 1.23]
4 Serious neonatal morbidity/perinatal death excluding major congenital malformations	2	2557	Risk Ratio (M‐H, Fixed, 95% CI)	3.00 [0.31, 28.82]
5 Serious maternal morbidity or death	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Cervix unfavourable or unchanged after 12/24 hours	1	90	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.30, 2.25]
8 Uterine hyperstimulation without FHR changes	5	2879	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.24, 1.70]
9 Uterine rupture	1	2517	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Epidural analgesia	6	2949	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [1.01, 1.17]
11 Instrumental vaginal delivery	9	3160	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.90, 1.21]
12 Meconium‐stained liquor	3	2801	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.65, 1.08]
13 Apgar score < 7 at 5 minutes	10	3367	Risk Ratio (M‐H, Fixed, 95% CI)	0.62 [0.35, 1.11]
14 Neonatal intensive care unit admission	5	2845	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.70, 1.04]
16 Perinatal death, excluding major congenital malformations	2	2555	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
19 Maternal nausea	3	162	Risk Ratio (M‐H, Fixed, 95% CI)	0.29 [0.03, 2.60]
20 Maternal vomiting	3	2584	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.27, 2.61]
21 Maternal diarrhoea	1	2517	Risk Ratio (M‐H, Fixed, 95% CI)	0.20 [0.01, 4.16]
23 Postpartum haemorrhage	2	2607	Risk Ratio (M‐H, Fixed, 95% CI)	0.96 [0.68, 1.36]
26 Women not satisfied	1	2517	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.84, 1.60]
28 Chorioamnionitis	4	2742	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.47, 0.92]
29 Endometritis	5	2762	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.54, 1.32]
30 Maternal antibiotics	2	2567	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.64, 1.08]
31 Neonatal infection	7	2948	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.42, 1.09]
32 Neonatal antibiotics	2	2564	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.53, 0.87]
33 Neonatal jaundice	1	36	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.11, 4.52]
35 Apgar score < 7 at 1 minute	2	2550	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.86, 1.28]