Skip to main content
. 2009 Oct 7;2009(4):CD003246. doi: 10.1002/14651858.CD003246.pub2

Valadan 2005.

Methods RCT.
Participants 91 women attending for induction indicated by post‐dates.
Inclusion criteria: singleton pregancy, cephalic presentation, intact membranes on admission, aged 16‐45 years, reassuring FHR, no more than 2 contactions in a 10‐minute period, Bishop score < or = 4.
Exclusion criteria: uterine scar after previous C/S, contraindication to vaginal delivery, vaginal bleeding, ruptured membranes, unstable pre‐eclampsia, suspected chorionamnionitis, contraindication to prostaglandin.
Interventions Both groups had routine amniotomy as early as possible after admission.
IV oxytocin. 6 mU/min increasing by 6 mU/min at 40 min intervals to max dose of 42 mU/min, unless signs of fetal distress or hyperstimulation
vs
intravaginal dinoprostone (PGE2) tablet. After 6 hrs Bishop score evaluated if less than 3 contractions per 10 mins then IV oxytocin started at same dose as above.
Outcomes Primary outcome: delivery within 24 hrs.
Notes Mean length of labour stated but not clear how many women delivered within 24 hours.
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk Described as "stratified randomisation technique".
Allocation concealment? Unclear risk Not stated.
Blinding? 
 Women High risk Not feasible.
Blinding? 
 clinical staff High risk  
Blinding? 
 outcome assessor High risk  
Incomplete outcome data addressed? 
 All outcomes Low risk  
Free of selective reporting? Unclear risk Not clear how many women delivered within 24 hours (this was stated as the primary outcome).