Skip to main content
. 2009 Oct 7;2009(4):CD003246. doi: 10.1002/14651858.CD003246.pub2
Study Reason for exclusion
Anderson 1971 Progress report. During the course of the study the protocol changed several times, study inclusion criteria changed several times so results were not presented by randomised group but for individual women. No usable data.
Andreasson 1985 Intranasal oxytocin.
Arulkumaran 1985 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Ashworth 1988 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Atad 1999 Abstract. No details of sample size. No usable data.
Auner 1993 Different IV oxytocin dosing regimens, pulsatile versus continuous. oxytocin. No placebo or expectant management arm.
Bergsjo 1969 Intranasal and buccal oxytocin.
Blackburn 1973 No prespecified outcomes reported.
Blakemore 1990 Different IV oxytocin dosing regimens. 
 15‐ versus 60‐minute dosing. 
 No placebo or expectant management arm.
Bredow 1990 All patients received intracervical PGE2 then were randomised to intravaginal PGE2 or oxytocin alone.
Bredow 1993 Not RCT. 
 Method of labour induction determined by Bishop score. 
 Bishop score < 5 ‐ intracervical PGE2 gel. 
 Bishop score 5‐8 ‐ vaginal PGE2 gel. 
 Bishop score > 8 ‐ intravenous oxytocin.
Bremme 1980 Uterine activity monitoring data.
Chestnut 1994 Early epidural vs late epidural in women receiving IV oxytocin.
Christensen 2001 Oxytocin used in combination with dinoprostone. Both arms of the trial received oxytocin. No placebo or expectant management arm.
Coleman 1997 Both groups received PGE2 gel, no group received oxytocin alone.
Crane 1993 Different IV oxytocin dosing regimens. 
 High versus low dosing. 
 No placebo or expectant management arm.
Cummiskey 1990 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Danezis 1962 Different oxytocins. 
 Synthetic vs natural. 
 No placebo or expectant management arm.
Daniel‐Spiegel 2004 Both groups received oxytocin. Different dosing regimens compared. 1 group discontinued oxytocin earlier. No placebo or expectant management arm.
Dawood 1995 Different IV oxytocin dosing regimens. 
 Pusatile versus continuous dosing. 
 No placebo or expectant management arm.
De Leon Casasola 1993 Fentanyl vs sufentanil epidural analgesia during labour.
Dietl 1987 Entry on trial register. No results reported. Not clear that trial completed.
Fuchs 2006 IV oxytocin was compared with misoprostol gel. This comparison is not relevant to this review, but is relevant to another review in the induction of labour series.
Gibb 1985 Different IV oxytocin dosing regimens. 
 Automatic infusion system vs peristaltic infusion system. 
 No placebo or expectant management arm.
Gillot 1974 Not IV oxytocin (intranasal).
Gloeb 1989 No outcomes reported.
Gonen 1997 Induction of labour with IV oxytocin and prostaglandins. 
 Cannot separate groups.
Goni 1995 Different IV oxytocin dosing regimens. 
 20‐ versus 60‐minute dosing. 
 No placebo or expectant management arm.
Hannah 1992 Intracervical PGs vs expectant management +/‐ IV oxytocin +/‐ amniotomy +/‐ immediate C/S. 
 Not possible to separate out data for oxytocin alone data from induction group.
Hendricks 1964 Intranasal oxytocin.
Hourvitz 1996 Different IV oxytocin dosing regimens. 
 High versus low dosing. 
 No placebo or expectant management arm.
Kashanian 2007 Both groups received oxytocin (oxytocin versus oxytocin plus propranolol, no placebo or active management arm).
Kjos 1993 IV oxytocin +/‐ vaginal PG cervical priming. 
 Not possible to separate oxytocin alone data.
Knox 1979 No prespecified outcomes reported.
Larsen 1983 Nasal oxytocin.
Lazor 1993 Different IV oxytocin dosing regimens. 
 15‐ versus 40‐minute dosing. 
 No placebo or expectant management arm.
Leszczynska‐Gorzelak 1993 No prespecified outcomes reported, main outcome was the presence of cortisol in amniotic fluid.
Lowensohn 1990 Different IV oxytocin dosing regimens. 
 15‐ versus 40‐minute dosing. 
 No placebo or expectant management arm.
MacLennan 1988 No useful published outcomes.
Mahmood 1995 Both groups in this study received IV oxytocin if labour had not started within 24 hours of hospital admission.
Mercer 1993 32‐36 weeks only.
Merrill 1999 Different IV oxytocin dosing regimens. 
 High versus low dosing. 
 No placebo or expectant management arm.
Milasinovic 1997 Oxytocin compared to complex intervention of combined endocervical and vaginal PGE2.
Moise 1991 No useful published outcomes.
Mokgokong 1974 No data presented on prespecified outcomes, participants were women with abnormal uterine action and cephalopelvic disproportion.
Mollo 1991 Insufficient data to extract.
Morgan‐Ortiz 2002 IV oxytocin was compared with vaginal misoprostol. This comparison is not relevant to this review, but is relevant to another review in the induction of labour series.
Morrison 1992 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Muller 1992 Different IV oxytocin dosing regimens. 
 30‐ versus 40‐minute dosing. 
 No placebo or expectant management arm.
Naef 1998 Induction of labour on 34 to 36+6 weeks. Not possible to separate out data relating to induction prior to 36 weeks' gestation.
Odem 1988 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Parpas 1995 Different IV oxytocin dosing regimens. 
 No placebo or expectant management arm.
Pentecost 1973 Buccal oxytocin.
Perales 1994 Uterine contractility study.
Raymond 1989 Different IV oxytocin dosing regimens. 
 Pulsatile versus continuous dosing. 
 No placebo or expectant management arm.
Rees 1991 Insufficient data to extract.
Ross 1998 Different IV oxytocin dosing regimens. 
 High versus low dosing. 
 No placebo or expectant management arm.
Salamalekis 2000 Pulsatile versus continuous oxytocin, no placebo or expectant management arm.
Satin 1991 Different IV oxytocin dosing regimens. 
 15‐ versus 30‐minute dosing. 
 No placebo or expectant management arm.
Satin 1994 Different IV oxytocin dosing regimens. 
 20‐ versus 40‐minute dosing. 
 No placebo or expectant management arm.
Shennan 1995 IV oxytocin vs placebo, but included all women at less than 6 cm who required augmentation or induction. Cannot separate out those in active labour.
Shennan 2006 Pulsatile versus continuous oxytocin.
Singh 1993 Different IV oxytocin dosing regimens. 
 High versus low dosing. 
 No placebo or expectant management arm.
Sjostedt 1969 Intranasal and buccal oxytocin.
Sorensen 1985 Buccal oxytocin.
Srividhya 2001 Case control intervention trial. Not clear that groups were randomised, unbalanced study groups.
Steer 1992 Some participants not randomly selected.
Tan 2007 Not IV oxytocin alone, both groups received dinoprostone.
Vernant 1993 No mention of gestational age.
Welt 1987 Abstract from trial register. No results reported. Not clear that study was carried out.
Willcourt 1994 Different IV oxytocin dosing regimens. 
 Pusatile versus continuous dosing. 
 No placebo or expectant management arm.

IV: intravenous 
 PG: prostaglandin 
 PGE2: prostaglandin E2 
 primips: primiparous 
 RCT: randomised controlled trials 
 vs: versus