FIG. 7.

Schematic view of the NHERF2-dependent regulation of LPA₂-mediated PLC-β3 signaling. Prior to agonist stimulation, both LPA₂ and PLC-β3 directly interact with NHERF2, which is localized to the plasma membrane. NHERF2, which is multimerized by a PDZ-PDZ interaction, clusters LPA₂ and PLC-β3 in close proximity, thereby creating spatially compact signaling complexes beneath the plasma membrane. Consequently, the LPA₂-NHERF2-PLC-β3 complex enables LPA₂ to transduce its signal to PLC-β3 with efficiency and specificity.