Table 4.
Kinetics of neutralizing antibody responses in animals vaccinated with TDV SC or ID using the PharmaJet device.
| NHP ID | Vaccine regimen | Day 30 |
Day 53 |
Day 88 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D1 | D2 | D3 | D4 | D1 | D2 | D3 | D4 | D1 | D2 | D3 | D4 | ||
| CY0503 | 0,0 | 40 | 1280 | 160 | 20 | 160 | 1280 | 40 | 10 | 80 | 5120 | 20 | 40 |
| CY0504 | PhJ/ID | 80 | 640 | 40 | 10 | 40 | 2560 | 40 | 5 | 80 | 2560 | 20 | 40 |
| CY0505 | 320 | 1280 | 2560 | 320 | 160 | 640 | 640 | 160 | 80 | 640 | 160 | 40 | |
| GMT* | 101 | 1016 | 254 | 40 | 101 | 1280 | 101 | 20 | 80 | 2032 | 40 | 40 | |
| CY0473 | 0,0 | 2560 | 10240 | 160 | 40 | 640 | 5120 | 80 | 20 | 320 | 1280 | 40 | 20 |
| CY0474 | PhJ/SC | 1280 | 320 | 1280 | 160 | 640 | 640 | 640 | 160 | 320 | 320 | 160 | 80 |
| CY0475 | 640 | 320 | 640 | 320 | 640 | 320 | 320 | 80 | 160 | 320 | 160 | 160 | |
| GMT | 1280 | 1016 | 508 | 127 | 640 | 1016 | 254 | 64 | 254 | 508 | 101 | 64 | |
| CY0493 | 0,60 | 160 | 2560 | 160 | 20 | 80 | 2560 | 10 | 20 | 320 | 2560 | 80 | 40 |
| CY0494 | PhJ/SC | 320 | 640 | 640 | 160 | 320 | 640 | 320 | 10 | 80 | 640 | 160 | 80 |
| CY0495 | 640 | 2560 | 320 | 40 | 640 | 2560 | 40 | 80 | 1280 | 2560 | 160 | 40 | |
| GMT | 320 | 1613 | 320 | 50 | 254 | 1613 | 50 | 25 | 320 | 1613 | 127 | 50 | |
GMT* = geometric mean titer.