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Effects of INS115644 on IOP in subjects with OHT and POAG. Following the fifth instillation (day 3) IOP decreased from baseline by 5.4 ± 2.4 mm Hg (P = 0.004) and 2.8 ± 2.7 mm Hg (P = 0.02) in the 0.02% and 0.05% cohorts, respectively, at 4 hours post instillation. Wilcoxon Signed-Rank test comparing IOP of active eye to placebo eye in Active-Placebo subjects.
