Table III.
Risk of clinical symptoms of hyperandrogenaemia, PCOS and infertility problems at 26 years of age in girls with or without menstrual irregularity at 16 years.
| Menstrual irregularity at 16 years | Clinical symptoms of hyperandrogenaemia, PCOS and infertility problems at 26 years |
|||
|---|---|---|---|---|
| Crude OR (95% CI) | P-value | Adjusteda OR (95% CI) | P-value | |
| Menstrual irregularity (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.55 (1.22–1.97) | <0.001 | 1.37 (1.00–1.88) | 0.050 |
| PCOSb (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 2.68 (1.79–4.03) | <0.001 | 2.91 (1.74–4.84) | <0.001 |
| Self-reported PCOS diagnosis (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 4.16 (2.28–7.60) | <0.001 | 5.53 (2.61–11.69) | <0.001 |
| Menstrual irregularity and hirsutism (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 2.26 (1.36–3.75) | 0.002 | 2.06 (1.06–4.02) | 0.034 |
| Hirsutism (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.26 (0.96–1.66) | 0.100 | 1.29 (0.92–1.81) | 0.141 |
| Acne (no/yes) | ||||
| No | 1.00 | |||
| Yes | 1.09 (0.88–1.36) | 0.413 | 1.16 (0.89–1.52) | 0.272 |
| Infertility problems (no/yes) | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.72 (1.092.72) | 0.021 | 2.07 (1.16–3.67) | 0.013 |
The analyses were performed with univariate and multivariate logistic regression.
OR, odds ratio; CI, confidence interval.
aAdjusted for consumption of alcohol (no/yes), smoking (no/yes), BMI (as continuous variable), annual income per consumption unit (as continuous variable) and age at menarche (as continuous variable).
bWomen with either self-reported PCOS diagnosis or both menstrual irregularity and hirsutism.