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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Expert Rev Cardiovasc Ther. 2008 Oct;6(9):1203–1215. doi: 10.1586/14779072.6.9.1203

Figure 1. Reverse cholesterol transport pathway.

Figure 1

ApoA-I acquires lipid in the liver and intestine to form nascent discoidal shaped HDL. This form of HDL can then efflux cholesterol from peripheral cells and return it back to the liver for excretion into the bile. This can occur either by hepatic uptake by SR-BI or by uptake of LDL after cholesteryl esters are transferred to LDL from HDL by CETP.

ABCA1: ATP-binding cassette transporter A–I; ApoA-I: Apolipoprotein A–I; CE: Cholesteryl esters; CETP: Cholesteryl ester transfer protein; LCAT: Lecithin:cholesterol acyltransferase; LDLR: LDL receptor; SR-BI: Scavenger receptor B–I; TG: Trigylcerides.