FIG. 8.

H19-Igf2 ICR hexad nuclear receptor binding sites in different species. (A) Mouse, rat, human, and sheep ICR sequences were analyzed for the presence of G/AGG/TTCA sites (arrows) on top and bottom strands. Note the higher frequency of sites in the upper strand. CTCF sites are indicated with black boxes. (B) As a control sequence, the mH19 gene was analyzed from kb +2 to +4.4. (C) Occurrence of G/AGG/TTCA sequences in the 1.2-kb chicken β-globin insulator. Numbers indicate locations of the analyzed sequences relative to the transcriptional start site in kilobases.