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. Author manuscript; available in PMC: 2015 Sep 11.
Published in final edited form as: Cell. 2014 Sep 11;158(6):1402–1414. doi: 10.1016/j.cell.2014.08.032

Figure 5. Thiopeptide BGCs are widespread in isolates and metagenomes of all main human body sites.

Figure 5

A) Five thiopeptide BGCs from human isolates, eight thiopeptide BGCs from human metagenomes, and one thiopeptide BGC from a pig isolate are shown. The label of each BGC indicates its body site of origin. B) Precursor peptides corresponding to the thiopeptide BGCs shown in A. Note that the precursor peptides fall into six subgroups of nearly identical sequences. The structural portion of the precursor peptide is shown in red (see also Figure S5 for a phylogenetic analysis of thiopeptide BGCs). C) A heat map showing the representation and abundance of six oral thiopeptide BGCs in HMP metagenomic oral samples (see also Table S2 for the quantification of all thiopeptide BGCs in all HMP samples). Note that although each BGC shown in the heat map is well represented in the oral cavity, most samples harbor only one thiopeptide BGC.