Table 3.
Association between measures of adiposity and progression to severe (IPSS ≥ 20) LUTS
| # Cases | # Person- Years |
HR (95% CI)* | HR (95% CI)† | ||
|---|---|---|---|---|---|
| Updated BMI (kg/m2) | |||||
| <21 | 55 | 1,502 | 0.73 (0.55 – 0.97) | 0.73 (0.55 – 0.98) | |
| 21 – <23 | 221 | 4,833 | 0.95 (0.80 – 1.12) | 0.95 (0.80 – 1.12) | |
| 23 – <25 | 406 | 8,932 | 1.0 (ref) | 1.0 (ref) | |
| 25 – <27.5 | 494 | 10,947 | 1.01 (0.88 – 1.15) | 1.02 (0.89 – 1.17) | |
| 27.5 – <30 | 291 | 5,471 | 1.22 (1.04 – 1.42) | 1.24 (1.06 – 1.45) | |
| 30 – <35 | 181 | 3,392 | 1.26 (1.05 – 1.51) | 1.30 (1.08 – 1.56) | |
| ≥ 35 | 43 | 766 | 1.44 (1.05 – 1.98) | 1.44 (1.04 – 2.00) | |
| p-trend | <0.0001 | <0.0001 | |||
|
Updated Waist Circumference (in) |
|||||
| ≤ 33 | 44 | 1,099 | 1.0 (ref) | 1.0 (ref) | |
| >33 – 34 | 150 | 3,747 | 1.02 (0.72 – 1.43) | 1.03 (0.73 – 1.45) | |
| >34 – 36 | 315 | 7,040 | 1.08 (0.78 – 1.49) | 1.10 (0.80 – 1.52) | |
| >36 – 38 | 373 | 8,107 | 1.11 (0.81 – 1.52) | 1.14 (0.83 – 1.58) | |
| >38 – 40 | 309 | 6,475 | 1.11 (0.81 – 1.54) | 1.15 (0.83 – 1.60) | |
| >40 – 42 | 220 | 4,271 | 1.22 (0.88 – 1.69) | 1.26 (0.90 – 1.76) | |
| > 42 | 280 | 5,105 | 1.27 (0.92 – 1.76) | 1.32 (0.95 – 1.85) | |
| p-trend | 0.007 | 0.005 | |||
|
Updated Hip Circumference (in) |
|||||
| ≤ 36 | 106 | 2,266 | 1.0 (ref) | 1.0 (ref) | |
| >36 – 38 | 314 | 6,993 | 0.93 (0.74 – 1.16) | 0.93 (0.74 – 1.17) | |
| >38 – 40 | 462 | 10,612 | 0.91 (0.74 – 1.13) | 0.92 (0.74 – 1.15) | |
| >40 – 42 | 393 | 8,247 | 0.98 (0.79 – 1.22) | 0.99 (0.79 – 1.25) | |
| >42 – 44 | 241 | 4,229 | 1.23 (0.98 – 1.56) | 1.24 (0.97 – 1.59) | |
| >44 – 46 | 91 | 1,987 | 0.94 (0.71 – 1.25) | 0.95 (0.70 – 1.27) | |
| > 46 | 84 | 1,510 | 1.14 (0.85 – 1.52) | 1.14 (0.84 – 1.55) | |
| p-trend | 0.02 | 0.02 | |||
|
Updated Waist to Hip Ratio |
|||||
| ≤ 0.87 | 133 | 2,986 | 1.0 (ref) | 1.0 (ref) | |
| >0.87 – 0.89 | 112 | 3,024 | 0.80 (0.62 – 1.03) | 0.81 (0.63 – 1.05) | |
| >0.89 – 0.91 | 182 | 3,944 | 0.94 (0.75 – 1.18) | 0.95 (0.76 – 1.20) | |
| >0.91 – 0.93 | 229 | 4,985 | 0.93 (0.75 – 1.16) | 0.95 (0.76 – 1.18) | |
| >0.93 – 0.95 | 258 | 5,553 | 0.94 (0.76 – 1.17) | 0.97 (0.78 – 1.20) | |
| >0.95 – 0.97 | 201 | 4,147 | 0.95 (0.76 – 1.19) | 0.98 (0.78 – 1.23) | |
| >0.97 – 0.99 | 189 | 3,903 | 0.98 (0.78 – 1.23) | 1.00 (0.79 – 1.26) | |
| ≥ 0.99 | 387 | 7,300 | 1.01 (0.83 – 1.24) | 1.04 (0.85 – 1.28) | |
| p-trend | 0.16 | 0.11 | |||
|
Weight Change from Age 21 (lbs) |
|||||
| Lost >10 | 177 | 3,746 | 1.08 (0.90 – 1.30) | 1.09 (0.91 – 1.32) | |
| No change (+/− 10) | 343 | 8,068 | 1.0 (ref) | 1.0 (ref) | |
| Gained 10 – <20 | 289 | 6,689 | 1.03 (0.88 – 1.21) | 1.05 (0.90 – 1.24) | |
| Gained 20 – <30 | 264 | 5,704 | 1.11 (0.94 – 1.30) | 1.14 (0.96 – 1.34) | |
| Gained 30 – <40 | 216 | 4,163 | 1.23 (1.04 – 1.47) | 1.27 (1.07 – 1.52) | |
| Gained 40 – <50 | 142 | 2,693 | 1.30 (1.06 – 1.58) | 1.36 (1.11 – 1.67) | |
| Gained 50+ | 260 | 4,779 | 1.31 (1.11 – 1.55) | 1.35 (1.14 – 1.60) | |
| p-trend | 0.0002 | <0.0001 | |||
*
Adjusted for age.
†
Adjusted for age, smoking in the past 10 years, physical activity, intake of total energy, polyunsaturated fatty acids, fruit, vegetables, red meat, alcohol, supplemental vitamin E, supplemental selenium, and use of aspirin. Models of waist circumference and hip circumference are further adjusted for height.