Table 2. Multivariate Logistic Regression for Evaluation of Risk Factors for Severe Retinopathy of Prematurity.
Model 1 (90 Days) All 684 Eyes with 76 Eyes Developing SROP |
Model 2 (105 Days) 468 ROP Eyes with 76 Eyes Developing SROP |
Model 3 (105 Days) 146 Prethreshold ROP Eyes with 76 Eyes Developing SROP |
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Beta | Odds Ratio (95% CI) | P Value | Beta | Odds Ratio (95% CI) | P Value | Beta | Odds Ratio (95% CI) | P Value | |
BW (each 100 g increase) | −0.475 | 0.62 (0.42–0.93) | 0.021 | −0.416 | 0.66 (0.44–0.98) | 0.039 | −0.136 | 0.87 (0.58–1.32) | 0.52 |
GA (wks) | − 0.643 | 0.53 (0.37–0.74) | <0.0005 | −0.566 | 0.57 (0.40–0.81) | 0.002 | −0.317 | 0.73 (0.52–1.02) | 0.067 |
Multiple birth (yes = 1, no = 0) | 1.889 | 6.6 (2.3–19.3) | 0.001 | 1.866 | 6.5 (2.2–18.9) | 0.001 | 2.247 | 9.5 (2.4–36.7) | 0.001 |
Race (black = 1, non-black = 0) | −1.612 | 0.20 (0.075–0.53) | 0.001 | −1.533 | 0.22 (0.079–0.59) | 0.003 | −0.774 | 0.32 (0.099–2.14) | 0.323 |
Gender (male = 1, female = 0) | 0.569 | 1.8 (0.78–3.99) | 0.171 | 0.546 | 1.7 (0.75–3.98) | 0.199 | 1.230 | 3.4 (1.12–10.5) | 0.031 |
Per capita income (each $10 000) | −0.056 | 0.95 (0.90–0.999) | 0.044 | −0.057 | 0.94 (0.90–0.995) | 0.033 | −0.042 | 0.96 (0.89–1.03) | 0.277 |
ADL (hours; cumulative 90 days after EDC) | −0.334 | 0.72 (0.55–0.94) | 0.015 | −0. | −0. | – | – | – | – |
ADL (hours; cumulative 105 days after EDC) | – | – | – | −0.363 | 0.70 (0.52–0.93) | 0.013 | −0.624 | 0.54 (0.37–0.78) | 0.001 |
ADL = average day length; BW = birth weight; CI = confidence interval; EDC = estimated date of conception; GA = gestational age; ROP = retinopathy of prematurity; SROP = severe retinopathy of prematurity.