Table 1. Effect of Human P450 Oxidoreductase (CPR) Genetic Variants on Cytochrome P450 Enzyme Activities with Different P450 Substratesa.
| CYP1A251 | CYP2C1951 | CYP2D652 |
CYP3A455 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| single POR mutations | EOMCCb | EOMCC | EOMCC | dextramethorphan | bufuralol | testosterone (6β-hydroxylation) | midazolam (1-hydroxylation) | quinidine | erythromycin |
| A115V | NDc | ND | |||||||
| Q153R | 144 | 284 | 128 | 198 | 153 | 129 | 94 | 150 | 76 |
| Y181D | ND | ND | |||||||
| A287P | ND | ND | ND | 27 | 24 | 17 | 17 | 3 | ND |
| R457H | ND | ND | ND | ND | ND | ND | ND | 1 | ND |
| V492E | ND | ND | |||||||
| A503V | 85 | 113 | 85 | 62 | 53 | 77 | 61 | 89 | 97 |
| C569Y | 6 | ND | |||||||
| V608F | 5 | ND | |||||||
a
Values represent percent of wild-type.
b
EOMCC: 2H-1-benzopyran-3-carbonitrile,7-(ethoxy-methoxy)-2-oxo-(9Cl).
c
ND, evaluated but undetectable.