Table 1.
Genes and pathways altered in Androgenetic Alopecia (AGA).
| Symbol | Cytobanda | Entrez gene name | Affymetrix ID | Fold change |
|---|---|---|---|---|
| Hair and skin development and function genes altered in AGA | ||||
| AR | Xq12 | Androgen receptor | 211110_s_at | 2.46 |
| AREG/AREGB | 4q13.3 | Amphiregulin | 205239_at | −2.3 |
| ARNTL2 | 12p12.2-p11.2 | Aryl hydrocarbon receptor nuclear translocator-like 2 | 224204_x_at | −12.13 |
| ATP2A2 | 12q24.11 | ATPase, Ca+ + transporting, cardiac muscle, slow twitch 2 | 212362_at | −2.46 |
| BARX2 | 11q25 | BARX homeobox 2 | 210419_at | −4.92 |
| BTC | 4q13.3 | Betacellulin | 241412_at | −2.64 |
| DAB2 | 5p13 | Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 210757_x_at | −2 |
| DCT | 13q32 | Dopachrome tautomerase | 205338_s_at | 2.3 |
| DDX5 | 17q21 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 225886_at | −2 |
| EGFR | 7p12 | Epidermal growth factor receptor | 201983_s_at | 2 |
| GAB1 | 4q31.21 | GRB2-associated binding protein 1 | 226002_at | −2 |
| INHBA | 7p15-p13 | Inhibin, beta A | 210511_s_at | 3.25 |
| IVL | 1q21 | Involucrin | 214599_at | −2 |
| KLK6 | 19q13.3 | Kallikrein-related peptidase 6 | 204733_at | −3.48 |
| KRT14 | 17q12-q21 | Keratin 14 | 209351_at | 2 |
| KRT27 | 10q32.1 | Keratin 27 | 240388_at | −4.92 |
| KRT32 | 17q21.2 | Keratin 32 | 207146_at | −2.64 |
| MAFF | 22q13.1 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 36711_at | −2 |
| MLL | 11q23 | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 1565436_s_at | 3.25 |
| MST4 | Xq26.2 | Serine/threonine protein kinase MST4 | 224407_s_at | −2.83 |
| MSX2 | 5q35.2 | Msh homeobox 2 | 205555_s_at | −2 |
| NRAS | 1p13.2 | Neuroblastoma RAS viral (v-ras) oncogene homolog | 202647_s_at | −2.64 |
| OGT | Xq13 | O-linked N-acetylglucosamine (GlcNAc) transferase | 207564_x_at | −3.73 |
| OVOL1 | 11q13 | Ovo-like 1(Drosophila) | 206604_at | −2 |
| PRKCI | 3q26.3 | Protein kinase C, iota | 213518_at | −2.3 |
| PSEN1 | 14q24.3 | Presenilin 1 | 207782_s_at | −2.14 |
| PTPRK | 6q22.2-q22.3 | Protein tyrosine phosphatase, receptor type, K | 233609_at | 2.3 |
| RHOB | 2p24 | Ras homolog gene family, member B | 1553962_s_at | −3.48 |
| RUNX3 | 1p36 | Runt-related transcription factor 3 | 204198_s_at | 4.59 |
| SGK3 | 8q12 | Serum/glucocorticoid regulated kinase family, member 3 | 243264_s_at | 3.48 |
| TGFBR3 | 1p33-p32 | Transforming growth factor, beta receptor III | 204731_at | 3.48 |
| TGM1 | 14q11.2 | Transglutaminase 1 | 206008_at | −2.14 |
| TIMP3 | 22q12.3 | TIMP metallopeptidase inhibitor 3 | 201149_s_at | 4.29 |
| TNFRSF19 | 13q12.11-q12.3 | Tumor necrosis factor receptor superfamily, member 19 | 223827_at | −2.64 |
| Notch signaling pathway genes altered in AGA | ||||
| ANK3 | 10q21 | Ankyrin 3, node of Ranvier | 209442_x_at | 2.14 |
| CNTN1 | 12q11-q12 | Contactin 1 | 227209_at | −2.46 |
| DCP1A | 3p21.1 | DCP1 decapping enzyme homolog A | 218508_at | 2.3 |
| DNER | 2q36.3 | Delta/notch-like EGF repeat containing | 226281_at | 2.64 |
| ESRRG | 1q41 | Estrogen-related receptor gamma | 207981_s_at | 3.25 |
| FAM49A | 2p24.2 | Family with sequence similarity 49, member A | 208092_s_at | −2.14 |
| GAS1 | 9q21.3-q22 | Growth arrest-specific 1 | 204456_s_at | −2.3 |
| GUCY1A3 | 4q31.1-q31.2 | Guanylate cyclase 1, soluble, alpha 3 | 221942_s_at | 2.3 |
| HES1 | 3q28-q29 | Hairy and enhancer of split 1 | 203394_s_at | 3.03 |
| HOXA5 | 7p15.2 | Homeobox A5 | 213844_at | 2.46 |
| HOXC6 | 12q13.3 | Homeobox C6 | 206858_s_at | 2.3 |
| JAG1 | 20p12.1-p11.23 | Jagged 1 | 209098_s_at | −2.46 |
| PNRC2 | 1p36.11 | Proline-rich nuclear receptor coactivator 2 | 222406_s_at | −2.3 |
| MLL | 11q23 | Myeloid/lymphoid or mixed-lineage leukemia | 1565436_s_at | 3.25 |
| NOTCH2 | 1p13-p11 | Notch 2 | 210756_s_at | −2.64 |
| NOTCH4 | 6p21.3 | Notch 4 | 205247_at | 2 |
| PHF20 | q11.23 | PHD finger protein 20 | 206567_s_at | 2.46 |
| PROX1 | 1q41 | Prospero homeobox 1 | 207401_at | 3.25 |
| PTN | 7q33 | Pleiotrophin | 209465_x_at | −3.25 |
| RUNX3 | 1p36 | Runt-related transcription factor 3 | 204198_s_at | 4.59 |
| SDC2 | 8q22-q23 | Syndecan 2 | 212158_at | −2.64 |
| SFRP1 | 8p11.21 | Secreted frizzled-related protein 1 | 202035_s_at | 3.73 |
| SLC17A6 | 11p14.3 | Solute carrier family 17 | 220551_at | 4 |
| SP4 | 7p15.3 | Sp4 transcription factor | 206663_at | 2.14 |
| SSR1 | 6p24.3 | Signal sequence receptor, alpha | 200890_s_at | −2.46 |
| WFDC2 | 20q13.12 | WAP four-disulfide core domain 2 | 203892_at | 2.3 |
| WNT2 | 7q31.2 | Wingless-type MMTV integration site family member 2 | 205648_at | 2.3 |
| ZEB1 | 10p11.2 | Zinc finger E-box binding homeobox 1 | 210875_s_at | −2.64 |
| ZNF24 | 18q12 | Zinc finger protein 24 | 203247_s_at | 2.14 |
Fold changes are indicated for each gene significantly under or overexpressed (p < 0.05, fold change >2) in androgenetic alopecia (AGA) compared to normal scalp. Positive data indicates overexpressed and negative data indicates under-expressed in AGA scalp.
a
Gene location obtained from National Center for Biotechnology Information public database (http://www.ncbi.nlm.nih.gov).