Table 6.
Longitudinal and cross-sectional analyses of sensitization in relation to exposure to Helicobacter pylori infection
| Longitudinal analysis of incident sensitization between ages 3 and 5 (N = 552)* | Overall N (%) | Outcome Yes n (%) | Outcome No n (%) | Crude OR (95% CI) | Adjusted OR† (95% CI) | P-value |
|---|---|---|---|---|---|---|
| H. pylori exposure at year 3 | ||||||
| No | 318 (57.6) | 7 (2.2) | 311 (97.8) | 1 | 1 | 0.72 |
| Yes | 234 (42.4) | 6 (2.6) | 228 (97.4) | 1.17 (0.39, 3.53) | 1.23 (0.40, 3.37) | |
| Cross-sectional analysis of sensitization at age 5 | ||||||
| H. pylori exposure at age 5 (N = 854) | ||||||
| No | 479 (56.1) | 14 (2.9) | 465 (97.1) | 1 | 1 | |
| Yes | 375 (43.9) | 3 (0.8) | 372 (99.2) | 0.27 (0.08, 0.94) | 0.26 (0.07, 0.92) | 0.02 |
| H. pylori exposure at ages 3 and 5 (N = 597)‡ | ||||||
| Never infected | 224 (37.5) | 7 (3.1) | 217 (96.9) | 1 | 1 | 0.36 |
| Infected at any age up to year 5 | 373 (62.5) | 7 (1.9) | 366 (98.1) | 0.59 (0.21, 1.71) | 0.61 (0.21, 1.76) | |
*
Reduced numbers as longitudinal analysis performed only on those reporting never sensitization at age 3.
†
ORs adjusted for child's gender, area of residence, and maternal education.
‡
Reduced numbers as H. pylori measured on subsample only at age 3.