Table 3.
Comparison of surgical (those undergoing PK and DSAEK, with or without cataract surgery) and nonsurgical patients with Fuchs endothelial corneal dystrophy
| Surgical | Nonsurgical | P-value | |
|---|---|---|---|
| Number | 197 (21%) | 748 (79%) | |
| PK | 96 (48.7%) | ||
| PK/CE/IOL | 35 (17.8%) | ||
| DSAEK | 35 (17.8%) | ||
| DSAEK/CE/IOL | 31 (15.7%) | ||
| Median VA, presentation | 20/60 | 20/40 | <0.001* |
| Median VA, worst‡ | 20/80 | 20/50 | <0.001* |
| Median lines of VA lost | 1 | 0 | <0.001* |
| Average (SD) corneal thickness | 634.5 (68.3) μm | 592 (48.0) μm | <0.001** |
| “3+” or “4+” corneal guttae | 185 (85%) | 454 (63%) | <0.001*** |
Notes:
‡
Recorded VA for surgical patients at the last visit prior to surgery, compared with the worst-recorded visual acuity throughout the follow-up period for the nonsurgical patients.
*
Mann–Whitney test.
**
Two-sample t-test.
***
Chi-squared test.
Abbreviations: CE, cataract extraction; DSAEK, descemet-stripping automated endothelial keratoplasty; IOL, intraocular lens implantation; PK, penetrating keratoplasty; SD, standard deviation; VA, Snellen visual acuity.