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. 2014 Sep 9;7:1571–1582. doi: 10.2147/OTT.S65055

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© 2014 Norton et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Surface receptor numbers with and without sunitinib treatment.

Notes: (A) The quantified number of surface vascular endothelial cell growth factor receptor 1 (VEGFR1) and VEGFR2 numbers in human umbilical vein endothelial cells (HUVEC). (B) The quantified number of surface VEGFR1 and VEGFR2 numbers in microvascular endothelial cells (MEC). These numbers were quantified using Quantibrite phycoerythrin beads. (C and D) MEC were treated in triplicate with 1 μM sunitinib or vehicle for 1.5 hours. (C) VEGFR2 increased significantly with sunitinib treatment, whereas VEGFR1 did not. (D) Receptor numbers for sunitinib-treated MEC cells were divided by the receptor numbers for the nontreated control. For VEGFR2, sunitinib treatment resulted in a fold-change that was statistically different from 1 (using a z-test). VEGFR1 was not statistically significant. *P<0.05; ***P<0.001.

Abbreviation: Ctrl, control.