Table 1. Demographics and clinical characteristics of the study populations.
Microarray | qRT-PCR | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Control Patients (n=61) |
Early-onset Preeclampsia (n=25) |
p-value | Late-onset Preeclampsia (n=47) |
p-value | Control Patients (n=99) |
Early-onset Preeclampsia (n=31) |
p-value | Late-onset Preeclampsia (n=72) |
p-value | |
Maternal Age (years) | 24.1 (16-39) | 24.0 (16-37) | 0.38 | 21.7 (16-36) | 0.07 | 24.3 (16-39) | 22.7 (16-37) | 0.21 | 21.8 (16-36) | 0.01 |
Nulliparity | 19 (31.1) | 14 (56.0) | 0.03 | 27 (57.4) | 0.006 | 29 (29.3) | 19 (61.3) | 0.001 | 41 (56.9) | <0.001 |
African American | 56 (91.8) | 21 (84.0) | 0.28 | 41 (87.2) | 0.44 | 85 (85.9) | 25 (80.6) | 0.48 | 66 (91.7) | 0.24 |
Tobacco Use | 4 (6.6) | 4 (16.0) | 0.17 | 9 (19.1) | 0.046 | 17 (17.2) | 5 (16.1) | 0.89 | 10 (13.9) | 0.56 |
BMI (kg/m2) | 27.1 (16.6-47.7) | 24.6 (13.8-35.9) | 0.04 | 26.4 (17.7-48.3) | 0.69 | 26.2 (16.4-54.9) | 24.7 (13.8-36.0) | 0.22 | 27.9 (16.5-52.4) | 0.37 |
Gestational Age at blood Draw (weeks) | 33.7 (20.0-40.1) | 31.1 (25.0-33.9) | 0.004 | 37.9 (34.3-41.4) | <0.001 | 34.7 (20.0-40.1) | 31.1 (24.7-34.0) | <0.001 | 38.1 (34.3-42.0) | <0.001 |
WBC Cells/mm3 | 8.0 (4.2-13.8) | 9.7 (6.7-18.7) | 0.002 | 8.3 (4.8-15.1) | 0.19 | 8.8 (2.7-18.7) | 9.7 (3.8-18.7) | 0.04 | 8.5 (4.8-23.6) | 0.63 |
Severe Preeclampsia | ---- | 22 (88.0) | ---- | 28 (59.6) | ---- | ---- | 26 (83.9) | ---- | 39 (54.2) | ---- |
Gestational Age at Delivery (weeks) | 39.1 (37.0-41.7) | 31.7 (26.1-34.0) | <0.001 | 38.0 (35.0-41.4) | <0.001 | 39.1 (37.0-42.1) | 31.7 (24.9-35.4) | <0.001 | 38.3 (35.0-42.1) | <0.001 |
Birthweight (grams) | 3390 (2575-4010) | 1235 (550-1910) | <0.001 | 2880 (1670-4180) | <0.001 | 3340 (2575-4010) | 1330 (474-2730) | <0.001 | 2968 (1670-4180) | <0.001 |
Birthweight <10%ile | 0 | 11 (44.0) | <0.001 | 15 (31.9) | <0.001 | 0 | 14 (45.2) | <0.001 | 18 (25.0) | <0.001 |
Data are expressed as median (range).
Data are expressed as count (% of group)
BMI: Body mass index
WBC: White blood cell counts