LNCaP (A), DU-145 (B) and PC-3 (C) cells were exposed to doxorubicin alone (Dox) or encapsulated in SPRL-E, G and SSL for 24, 48, and 72 hours, after which cells were detached, washed, and assessed for fluorescence using flow cytometry. Data are presented as the mean +/- SEM of at least 3 different experiments. “a” Denotes a significant (P < 0.05) difference between Dox and SSL, “b” denotes a significant difference between Dox and SPRL-G. There were no significant differences between Dox and SPRL-E.